The timing of cyclophosphamide therapy in tumor-bearing rats affects the resistance to tumor challenge in survivors

Experientia. 1978 Oct 15;34(10):1355-6. doi: 10.1007/BF01981468.

Abstract

Cyclophosphamide given to rats 2 or 5 days after an injection of Yoshida ascites sarcoma cured approximately the same proportion of animals, but the resistance to a subsequent tumor challenge was found only in rats treated with the drug 5 days after tumor injection.

MeSH terms

  • Animals
  • Cyclophosphamide / administration & dosage*
  • Cyclophosphamide / therapeutic use
  • Drug Administration Schedule
  • Female
  • Immunosuppression Therapy
  • Male
  • Rats
  • Sarcoma, Yoshida / drug therapy*
  • Sarcoma, Yoshida / immunology

Substances

  • Cyclophosphamide