Synthesis and analgesic activity of N-substituted 6,7-benzomorphans

Farmaco Sci. 1980 Jun;35(6):490-7.

Abstract

Some new N-substituted 6,7-benzomorphans were prepared and tested for analgetic activity. The compounds (I) and (II), which proved the most active in a preliminary screening, were submitted to a more detailed investigation, and their ED50 was determined in mice by the phenylquinone, hot-plate and tail-pinch tests. Studies of acute toxicity and physical dependence capacity were also performed.

MeSH terms

  • Analgesics / chemical synthesis*
  • Analgesics / toxicity
  • Animals
  • Benzomorphans / analogs & derivatives
  • Benzomorphans / chemical synthesis*
  • Benzomorphans / pharmacology
  • Benzomorphans / toxicity
  • Chemical Phenomena
  • Chemistry
  • Lethal Dose 50
  • Mice
  • Morphinans / chemical synthesis*

Substances

  • Analgesics
  • Benzomorphans
  • Morphinans