The behaviour of fibrinogen, haptoglobin alpha 1-acid GP, ceruloplasmin, alpha 2-macroglobulin and alpha 2-HS in patients with acute myocardial infarction (in the initial stage and in the following two weeks), chronic ischaemic heart disease, chronic atherosclerotic vascular disease and hyperlipoproteinemia was evaluated. According to the obtained results the utility of their evaluation is evident and, especially for the chronic situations, some therapeutic considerations emerge.