Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity

J Med Chem. 1995 Oct 13;38(21):4161-3. doi: 10.1021/jm00021a004.

Authors

G L Bundy¹, D E Ayer, L S Banitt, K L Belonga, S A Mizsak, J R Palmer, J M Tustin, J E Chin, E D Hall, K L Linseman, et al.

Affiliation

¹ Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001, USA.

PMID: 7473542
DOI: 10.1021/jm00021a004

No abstract available

MeSH terms

Animals
Anti-Asthmatic Agents / chemical synthesis*
Antioxidants / chemical synthesis*
Biological Availability
Magnetic Resonance Spectroscopy
Male
Mice
Molecular Structure
Neuroprotective Agents / chemical synthesis*
Pyrimidines / chemical synthesis*
Pyrimidines / pharmacokinetics
Pyrimidines / therapeutic use
Pyrrolidines / chemical synthesis*
Pyrrolidines / pharmacokinetics
Pyrrolidines / therapeutic use
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Anti-Asthmatic Agents
Antioxidants
Neuroprotective Agents
Pyrimidines
Pyrrolidines
U 104067