Regulatory genes of simian immunodeficiency viruses from west African green monkeys (Cercopithecus aethiops sabaeus)

V Jubier-Maurin; P Sarni-Manchado; F Veas; N Vidal; F Bibollet-Ruche; J P Durand; A Galat-Luong; G Cuny

doi:10.1128/JVI.69.11.7349-7353.1995

Regulatory genes of simian immunodeficiency viruses from west African green monkeys (Cercopithecus aethiops sabaeus)

J Virol. 1995 Nov;69(11):7349-53. doi: 10.1128/JVI.69.11.7349-7353.1995.

Authors

V Jubier-Maurin¹, P Sarni-Manchado, F Veas, N Vidal, F Bibollet-Ruche, J P Durand, A Galat-Luong, G Cuny

Affiliation

¹ Laboratoire Rétrovirus, Institute Français de Recherche Scientifique pour le Développment en Coopération (ORSTOM), Montpellier, France.

Abstract

The high seroprevalence of simian immunodeficiency viruses (SIVs) in African green monkeys (AGMs) without immunological defects in their natural hosts has prompted consideration of SIV-infected AGMs as a model of apathogenic SIV infection. Study of the molecular mechanisms of SIVagm asymptomatic infection could thus provide clues for understanding the pathogenesis of human immunodeficiency viruses. Regulatory genes could be candidates for genetic control of SIVagm apathogenicity. We have characterized Vpr, Tat, Rev, and Nef genes of two SIVagm strains isolated from naturally infected sabaeus monkeys captured in Senegal. The results provide further evidence that SIVagm from West African green monkeys is the most divergent class of AGM viruses, with structural features in long terminal repeat sequences and Vpr and Tat genes that distinguish them from viruses isolated from other AGM species (vervet, grivet, and tantalus monkeys).

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Africa, Western
Amino Acid Sequence
Animals
Chlorocebus aethiops / virology*
Exons
Gene Products, nef / chemistry
Gene Products, nef / genetics
Gene Products, tat / chemistry
Gene Products, tat / genetics
Gene Products, vpr / chemistry
Gene Products, vpr / genetics
Genes, Regulator*
Genes, Viral*
HIV / pathogenicity
Humans
Molecular Sequence Data
Phylogeny*
Sequence Homology, Amino Acid
Simian Immunodeficiency Virus / genetics*
Simian Immunodeficiency Virus / isolation & purification
Simian Immunodeficiency Virus / pathogenicity
nef Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus
vpr Gene Products, Human Immunodeficiency Virus

Substances

Gene Products, nef
Gene Products, tat
Gene Products, vpr
nef Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus
vpr Gene Products, Human Immunodeficiency Virus

Associated data

GENBANK/U20811
GENBANK/U20812
GENBANK/U20813
GENBANK/U20814
GENBANK/U20965
GENBANK/U20966
GENBANK/U20967
GENBANK/U20968
GENBANK/U21093