Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling

Ann N Y Acad Sci. 1995 Sep 7:766:388-401. doi: 10.1111/j.1749-6632.1995.tb26688.x.
No abstract available

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Enzyme Activation
  • ErbB Receptors / chemistry
  • ErbB Receptors / physiology
  • Humans
  • Insulin / metabolism
  • Insulin / pharmacology
  • Insulin / physiology
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Like Growth Factor I / pharmacology
  • Insulin-Like Growth Factor I / physiology
  • Kinetics
  • Ligands
  • Macromolecular Substances
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases*
  • Models, Structural
  • Models, Theoretical
  • Receptor, IGF Type 1 / chemistry
  • Receptor, IGF Type 1 / physiology*
  • Receptor, Insulin / chemistry
  • Receptor, Insulin / physiology*
  • Receptors, Cytokine / chemistry
  • Receptors, Cytokine / physiology
  • Receptors, Platelet-Derived Growth Factor / chemistry
  • Receptors, Platelet-Derived Growth Factor / physiology
  • Second Messenger Systems
  • Signal Transduction*
  • Substrate Specificity

Substances

  • Insulin
  • Ligands
  • Macromolecular Substances
  • Receptors, Cytokine
  • Insulin-Like Growth Factor I
  • ErbB Receptors
  • Receptor, IGF Type 1
  • Receptor, Insulin
  • Receptors, Platelet-Derived Growth Factor
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases