Abstract
A series of xanthone 1,4-dihydropyridine derivatives bearing a 2,3-lactone ring and a 2-acetoxymethyl group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The introduction of a 2,3-lactone ring improved the negative inotropic activity and selectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium Channel Blockers / chemical synthesis*
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Calcium Channel Blockers / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Female
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Guinea Pigs
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Heart Atria / drug effects
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Heart Rate / drug effects
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In Vitro Techniques
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Lactones / chemical synthesis*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Structure-Activity Relationship
Substances
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Calcium Channel Blockers
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Lactones
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Pyridines
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hydroxypyridines