Abstract
The genomic organization and nucleotide structure of the human cone photoreceptor cGMP phosphodiesterase alpha'-subunit (alpha'-PDE) gene (PDEA2) as well as its chromosomal localization have been determined. This gene, which spans about 48 kb, consists of 22 exons and codes for an 858-amino-acid protein. The alpha'-PDE gene maps to human chromosome 10q24. Its coding region shows about 90% nucleotide identity and 93% amino acid identity with the corresponding region of the bovine gene. The intron-exon organization of the genes encoding human cone alpha'-PDE and rod beta-PDE are very similar, suggesting that these proteins have a close phylogenetic relationship and probably a common origin.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3',5'-Cyclic-GMP Phosphodiesterases / genetics*
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Chromosome Mapping
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Chromosomes, Human, Pair 10*
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Cloning, Molecular
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Cyclic Nucleotide Phosphodiesterases, Type 6
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DNA
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Eye Proteins / genetics*
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Humans
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Molecular Sequence Data
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Retinal Cone Photoreceptor Cells / enzymology*
Substances
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Eye Proteins
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DNA
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3',5'-Cyclic-GMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 6
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PDE6C protein, human
Associated data
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GENBANK/U20196
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GENBANK/U20197
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GENBANK/U20198
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GENBANK/U20199
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GENBANK/U20200
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GENBANK/U20201
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GENBANK/U20202
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GENBANK/U20203
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GENBANK/U20204
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GENBANK/U20205
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GENBANK/U20206
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GENBANK/U20207
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GENBANK/U20208
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GENBANK/U20209
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GENBANK/U20210
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GENBANK/U20211
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GENBANK/U20212
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GENBANK/U31973