Eighteen healthy males with a body weight of 70.0 +/- 3.1 kg consumed three defined-formula diets that varied only in their fiber and/or lipid components: 1) 6.4% fiber (100% soy polysaccharides) and 13.1% lipid [50% medium-chain triacylglycerols (MCTs), 40% corn oil, and 10% soy oil]; 2) 3.4% fiber (75% oat fiber, 17.5% gum arabic, and 7.5% carboxymethylcellulose) and 15.6% lipid (20% MCTs, 50% canola oil, and 30% high oleic acid safflower oil); and 3) 4.4% fiber (same as diet 2) and 14.5% lipid (same as diet 1). Consumption of diet 2 resulted in slightly firmer stools and provided the greatest amount of fecal output per unit fiber intake. Total dietary fiber (TDF) digestibility was lowest for men fed diets 2 and 3, but nitrogen and lipid digestibilities and energy metabolism criteria were not different among diets. Although mineral excretion patterns differed among treatments, fiber and lipid components of the diets appeared not to be responsible for these differences. Results indicate that fecal output can be maintained with a lower intake of a blend of oat fiber, gum arabic, and carboxymethylcellulose compared with soy polysaccharides. Except for TDF digestibility, alteration of amounts and/or sources of fiber and lipid components of defined-formula diets used in this experiment did not alter nutrient digestibility, energy metabolism, or mineral retention.