Abstract
Two new withanolides, 14,15 beta-epoxywithanolide I [(20S,22R) 17 beta, 20 beta-dihydroxy-14 beta,15 beta-epoxy-1-oxo-witha-3,5,24-trienolide] and 17 beta-hydroxywithanolide K (20S,22R) 14 alpha,17 beta,20 beta-trihydroxy-1-oxo-witha-2,5,24-trienolide] have been isolated from the whole plant of Withania coagulance and their structures were elucidated by spectroscopic techniques. The latter compound was found to be active against a number of potentially pathogenic fungi.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Chromatography, Thin Layer
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Ergosterol / analogs & derivatives*
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Ergosterol / chemistry
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Ergosterol / isolation & purification
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Ergosterol / pharmacology
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Plants / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
Substances
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14,15-epoxywithanolide I
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17-hydroxywithanolide K
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Antifungal Agents
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Lactones
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Ergosterol