Abstract
A new series of 2-substituted-7,8-dimethyl-3H,9H-thieno[2',3':4,5]pyrimido[2,1- b][1,3,4]thiadiazin-9-ones 5a-d and 6a,b was synthesized through the hydrazinium(1+) salt of 3-amino-2,3-dihydro-5,6-dimethyl-2-thioxo- thieno[2,3-d]pyrimidin-4(1H)-one, 2. These derivatives and two analogs 10a,b were tested for their analgesic and antiinflammatory properties. The pharmacological results are discussed in comparison with those of related compounds previously tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Spectrophotometry, Infrared
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Thiadiazines / chemical synthesis*
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Thiadiazines / pharmacology
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Pyrimidines
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Thiadiazines