To determine the seroprevalence of infection with the human immunodeficiency virus (HIV) in pulmonary tuberculosis patients, we conducted an HIV serosurvey in 162 inpatients with pulmonary tuberculosis, in Yaoundé Cameroon. HIV seroprevalence in hospitalized pulmonary tuberculosis patients was found to be 9.9% as compared to the seroprevalence rate of 2.2% for Yaounde, the area from which the patients we studied came. No differences were observed in the clinical, radiological and bacteriological features between HIV seropositive and seronegative patients with pulmonary tuberculosis.