Plater's description of Dupuytren's disease in 1614 is explained with regard to his understanding of the anatomy. The current view that Plater believed the disease to be caused by dislocation and shortening of the flexor tendons is based upon misinterpretation of the original Latin text. With the help of his anatomical studies, Plater had proven that subcutaneous ligamentous extensions of the palmar aponeurosis and not the flexor tendons were responsible for Dupuytren's disease. Felix Plater realised more than one hundred and fifty years before Cline, Cooper, and Dupuytren the palmar aponeurosis as the anatomical substrate of the disease.