Abstract
Rhesus monkeys were immunized by the vaginal and oral routes using a recombinant particulate simian immunodeficiency virus (SIV) antigen. Augmenting vaginal by oral immunization in macaques elicits proliferative CD4+ T cells in the circulation which are specific to the immunizing p27 antigen. Reconstitution of enriched CD4+ T cells, B cells and macrophages from circulating mononuclear cells help B cells in specific IgA anti-p27 antibody synthesis. The results suggest that augmented vaginal immunization induces systemic CD4+ T and B cell responses which may play a part in the protective immunity against SIV (HIV) infection.
MeSH terms
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Administration, Intravaginal
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Administration, Oral
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Animals
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Antibodies, Viral / biosynthesis
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Antigens, Viral / administration & dosage*
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B-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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Female
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Gene Products, gag / administration & dosage*
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Gene Products, gag / immunology*
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HIV Infections / immunology
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HIV Infections / prevention & control
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HIV Infections / transmission
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Humans
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Immunity, Mucosal
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Immunization*
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Lymphocyte Activation
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Macaca fascicularis
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Macaca mulatta
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SAIDS Vaccines / administration & dosage
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Simian Immunodeficiency Virus / immunology*
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T-Lymphocytes / immunology*
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Vagina / immunology*
Substances
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Antibodies, Viral
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Antigens, Viral
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Gag protein p27, Simian immunodeficiency virus
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Gene Products, gag
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SAIDS Vaccines