Abstract
The L-arginine derived NO-cGMP pathway's role in the response of the arterial wall to balloon catheter injury was examined. Rats were given the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (10 mg/kg po twice daily) or vehicle for 6 days before and 2 weeks after balloon catheter injury. NG-nitro-L-arginine methyl ester treatment increased blood pressure and inhibited acetylcholine responses in aortic rings but did not alter the lesions produced by balloon injury. Our results suggest that the L-arginine derived NO-cGMP pathway does not play a significant role in the response of the artery wall to balloon injury in the rat.
MeSH terms
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Acetylcholine / pharmacology
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Amino Acid Oxidoreductases / antagonists & inhibitors*
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Animals
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Arginine / analogs & derivatives*
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Arginine / pharmacology
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Blood Pressure / drug effects
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Carotid Arteries / drug effects
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Carotid Arteries / pathology*
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Carotid Artery Injuries
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Catheterization*
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Cyclic GMP / metabolism
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Dose-Response Relationship, Drug
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Hyperplasia / etiology*
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In Vitro Techniques
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Male
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NG-Nitroarginine Methyl Ester
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Nitric Oxide / metabolism
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Nitric Oxide Synthase
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Rats
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Rats, Sprague-Dawley
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Tunica Intima / drug effects
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Tunica Intima / injuries
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Tunica Intima / pathology*
Substances
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Nitric Oxide
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Arginine
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases
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Cyclic GMP
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Acetylcholine
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NG-Nitroarginine Methyl Ester