Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX)

Adv Exp Med Biol. 1993:338:635-8. doi: 10.1007/978-1-4615-2960-6_131.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Cell Line
  • Drug Resistance / physiology*
  • Humans
  • Hydrogen-Ion Concentration
  • Kinetics
  • Leukemia, Lymphoid
  • Methotrexate / analogs & derivatives
  • Methotrexate / analysis
  • Methotrexate / metabolism
  • Methotrexate / toxicity*
  • Polyglutamic Acid / analogs & derivatives
  • Polyglutamic Acid / analysis
  • Polyglutamic Acid / metabolism
  • Tumor Cells, Cultured
  • gamma-Glutamyl Hydrolase / metabolism*

Substances

  • Polyglutamic Acid
  • methotrexate polyglutamate
  • gamma-Glutamyl Hydrolase
  • Methotrexate