Abstract
Detection of subjects from a multiple endocrine neoplasia type 1 family must rest on clinical, biochemical and radiological data, since study of the genome is unable to detect these subjects. In the new family described here, 6 out of the 14 subjects explored were affected. One had a confirmed pancreatic endocrine tumour and in 3 others a pancreatic endocrine tumour was highly probable, since insulin and glucagon levels, as well as ultrasonic exploration of the pancreas were pathological. Measurements of gastrointestinal hormones gave normal results in all cases. We conclude that to detect this endocrine neoplasia in subjects at risk it seems necessary to measure plasma insulin levels and perform an abdominal ultrasonography.
MeSH terms
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Adolescent
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Adult
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Aged
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Blood Glucose / analysis
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C-Peptide / analysis
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Child
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Female
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Gastrins / analysis*
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Glucagon / analysis
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Humans
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Insulin / blood
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Male
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Middle Aged
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Multiple Endocrine Neoplasia / blood
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Multiple Endocrine Neoplasia / genetics
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Multiple Endocrine Neoplasia / prevention & control*
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Pancreatic Neoplasms / blood
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Pancreatic Neoplasms / diagnostic imaging
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Pancreatic Neoplasms / genetics
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Pancreatic Neoplasms / prevention & control*
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Pancreatic Polypeptide / analysis*
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Pituitary Neoplasms / blood
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Pituitary Neoplasms / genetics
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Pituitary Neoplasms / prevention & control*
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Risk Factors
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Substance P / analysis
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Ultrasonography
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Vasoactive Intestinal Peptide / analysis
Substances
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Blood Glucose
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C-Peptide
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Gastrins
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Insulin
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Substance P
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Vasoactive Intestinal Peptide
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Pancreatic Polypeptide
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Glucagon