Abstract
The distribution of three immunoglobulin heavy chain variable region gene subgroups (VH1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the VH5 subgroup was observed relative to its small size.
MeSH terms
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Antigens, CD / genetics
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Base Sequence
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Bias
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CD5 Antigens
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DNA / genetics*
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Gene Expression Regulation, Neoplastic / genetics*
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Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics*
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Genetics, Population*
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Genome
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Humans
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Immunoglobulin Variable Region / genetics*
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Leukemia, Lymphocytic, Chronic, B-Cell / blood
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Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Lymphocytes
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Molecular Sequence Data
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Polymerase Chain Reaction
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Stochastic Processes
Substances
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Antigens, CD
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CD5 Antigens
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Immunoglobulin Variable Region
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DNA