Neurotrophic effects of substance P on hippocampal neurons in vitro

Neurosci Lett. 1993 Dec 24;164(1-2):141-4. doi: 10.1016/0304-3940(93)90877-n.

Abstract

The potential neurotrophic effect of substance P-like immunoreactivity present in culture media was assessed in rat embryonic day 18 hippocampal cultures. The neurokinin-1 (substance P) receptor antagonist CP-96345 induced neurotoxicity that was dose dependent and attenuated by addition of substance P or the neurokinin-1 agonist [Sar9,Met(O2)11]-SP. These studies suggest that under some conditions neurokinin-1 receptor stimulation promotes neuronal survival.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biphenyl Compounds / pharmacology
  • Biphenyl Compounds / toxicity
  • Cells, Cultured
  • Culture Media, Conditioned
  • Hippocampus / cytology*
  • Hippocampus / drug effects
  • Neurokinin-1 Receptor Antagonists
  • Neurons / drug effects*
  • Polymerase Chain Reaction
  • RNA, Messenger / biosynthesis
  • Rats
  • Receptors, Neurokinin-1 / drug effects
  • Substance P / pharmacology*

Substances

  • Biphenyl Compounds
  • Culture Media, Conditioned
  • Neurokinin-1 Receptor Antagonists
  • RNA, Messenger
  • Receptors, Neurokinin-1
  • Substance P
  • CP 96345