Abstract
We examined the eosinophil viability-enhancing activity (EVEA) of peripheral blood mononuclear cells (PBMNCs) obtained from mite-sensitive bronchial asthma (BA) and normal control subjects. Mite concentrations of 1 and 10 micrograms/ml significantly increased EVEA in BA patients as compared with normal controls (p < 0.05 and p < 0.05, respectively). The level of IFN-gamma in PBMNC culture supernatants was higher in BA patients than in normal controls. Dexamethasone, cyclosporin A and FK506 significantly inhibited EVEA in BA patients (p < 0.05 to p < 0.001).
MeSH terms
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Allergens / adverse effects*
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Animals
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Antibodies / pharmacology
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Asthma / immunology*
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Asthma / metabolism
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Cell Survival / drug effects
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Cell Survival / immunology
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Cyclosporine / pharmacology
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Cytokines / biosynthesis*
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Dexamethasone / pharmacology
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Eosinophils / cytology
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Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis
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Granulocyte-Macrophage Colony-Stimulating Factor / immunology
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Humans
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Interferon-gamma / biosynthesis
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Interferon-gamma / immunology
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Interleukin-3 / biosynthesis
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Interleukin-3 / immunology
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Interleukin-5 / biosynthesis
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Interleukin-5 / immunology
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Mites / immunology*
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Tacrolimus / pharmacology
Substances
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Allergens
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Antibodies
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Cytokines
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Interleukin-3
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Interleukin-5
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Dexamethasone
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Interferon-gamma
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Granulocyte-Macrophage Colony-Stimulating Factor
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Cyclosporine
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Tacrolimus