Assignment of the human gene for the water channel of renal collecting duct Aquaporin 2 (AQP2) to chromosome 12 region q12-->q13

Cytogenet Cell Genet. 1994;66(4):260-2. doi: 10.1159/000133707.

Abstract

The chromosomal localization of the gene encoding Aquaporin 2 (previously called WCH-CD), which acts as a water channel in the collecting tubules of the kidney, was determined. Southern blot hybridizations of chromosomal DNA from a panel of 25 different human-rodent hybrid cell lines assigned AQP2 to the q-arm of human chromosome 12. Additionally, in situ hybridization on R-banded metaphase chromosomes localized AQP2 to the q12-->q13 region of this chromosome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins*
  • Chromosome Banding
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • DNA Primers
  • Humans
  • Ion Channels / genetics*
  • Membrane Proteins / genetics*
  • Polymerase Chain Reaction
  • Restriction Mapping

Substances

  • AQP2 protein, human
  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins
  • DNA Primers
  • Ion Channels
  • Membrane Proteins