Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor

Am J Pediatr Hematol Oncol. 1994 May;16(2):160-3.

Abstract

Patient: A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG).

Methods and results: With the addition of granulocyte colony-stimulating factor (G-CSF; Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 10(9)/L to 3.36 x 10(9)/L, and he has been free of significant infection for the past 22 months.

Conclusions: The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Genetic Linkage
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Hypergammaglobulinemia / blood
  • Hypergammaglobulinemia / complications
  • Hypergammaglobulinemia / therapy*
  • Immunoglobulin M / blood*
  • Immunoglobulins, Intravenous / therapeutic use
  • Male
  • Neutropenia / therapy*
  • Syndrome
  • X Chromosome

Substances

  • Immunoglobulin M
  • Immunoglobulins, Intravenous
  • Granulocyte Colony-Stimulating Factor