Abstract
We herein report a case of acute myeloid leukaemia (AML, FAB:M0) who showed upregulation of T-lymphoid antigens (CD2, CD7) and adhesion molecules (CD11a, CD11b, CD18) on leukaemic cells after in vivo administration of granulocyte colony-stimulating factor (G-CSF). To our knowledge, this is the first report which describes in vivo changes of cell surface antigen expression on AML cells after the administration of G-CSF.
Publication types
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Case Reports
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Comparative Study
MeSH terms
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Aclarubicin / administration & dosage
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Acute Disease
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Aged
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Antigens, CD / drug effects*
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Antigens, CD / immunology
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Antigens, Surface / drug effects
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Antigens, Surface / immunology
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bone Marrow / drug effects
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Bone Marrow / immunology
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Bone Marrow Cells
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Cell Adhesion Molecules / drug effects*
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Cell Adhesion Molecules / immunology
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Cell Separation
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Cytarabine / administration & dosage
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Female
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Flow Cytometry
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Granulocyte Colony-Stimulating Factor / administration & dosage*
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Humans
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Leukemia, Myeloid / drug therapy
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Leukemia, Myeloid / immunology*
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
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Up-Regulation / drug effects*
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Up-Regulation / immunology
Substances
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Antigens, CD
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Antigens, Surface
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Cell Adhesion Molecules
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Cytarabine
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Granulocyte Colony-Stimulating Factor
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Aclarubicin