Assessment of occupational exposure to diesel exhaust. The use of an immunoassay for the determination of urinary metabolites of nitroarenes and polycyclic aromatic hydrocarbons

Toxicol Lett. 1994 Jun;72(1-3):191-8. doi: 10.1016/0378-4274(94)90028-0.

Abstract

In a repair shop for train engines a pilot study was conducted to investigate occupational exposure to diesel exhaust. 1-Nitropyrene was determined in stationary sampled total suspended particulate matter collected on 2 consecutive workdays. Air concentrations of particulate associated 1-nitropyrene varied from non-detectable to 5.6 ng/m3. In spot urine samples collected on Sunday, Monday and Tuesday urinary metabolites of polycyclic aromatic hydrocarbons and their nitro-substituted derivatives were determined using an immunoassay. In the urine samples of 3 diesel mechanics both cumulative and average excretion of urinary metabolites over 48 and 72 h were significantly enhanced (P < 0.05) as compared to the excreted levels in urine samples from 2 office clerks.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunoassay
  • Male
  • Nitro Compounds / metabolism
  • Nitro Compounds / urine*
  • Occupational Exposure*
  • Polycyclic Compounds / metabolism
  • Polycyclic Compounds / urine*
  • Pyrenes / metabolism
  • Vehicle Emissions / adverse effects*

Substances

  • Antibodies
  • Nitro Compounds
  • Polycyclic Compounds
  • Pyrenes
  • Vehicle Emissions
  • 1-aminopyrene
  • 1-nitropyrene