The response of diffuse large cell and other intermediate grade non-Hodgkin's lymphomas to adriamycin containing combination chemotherapy

Leuk Lymphoma. 1994 Mar;13(1-2):131-6. doi: 10.3109/10428199409051663.

Abstract

Adriamycin containing combination chemotherapy (ACCC) is usually delivered to patients with stages III, IV diffuse large cell (DLCL) non-Hodgkin's lymphoma (NHL). Although this mode of therapy is also commonly used in other intermediate grade lymphomas, it's role in the latter subset of patients is not well defined. In a retrospective analysis we evaluated and compared the outcome of previously untreated DLCL and non-DLCL intermediate grade lymphoma patients who received as initial therapy, "first generation" ACCC. No differences in response and relapse rates between these subgroups were observed. The trend towards the survival advantage observed for the non-DLCL patients, is probably due to a lower mortality over 5-8 years, for complete responders.

Publication types

  • Comparative Study

MeSH terms

  • Actuarial Analysis
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Cisplatin / administration & dosage
  • Cyclophosphamide / administration & dosage
  • Dexamethasone / administration & dosage
  • Doxorubicin / administration & dosage
  • Doxorubicin / therapeutic use*
  • Etoposide / administration & dosage
  • Follow-Up Studies
  • Humans
  • Leucovorin / administration & dosage
  • Lomustine / administration & dosage
  • Lymphoma, Large B-Cell, Diffuse / drug therapy*
  • Lymphoma, Large B-Cell, Diffuse / mortality
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Lymphoma, Non-Hodgkin / drug therapy*
  • Lymphoma, Non-Hodgkin / mortality
  • Lymphoma, Non-Hodgkin / pathology
  • Melphalan / administration & dosage
  • Methotrexate / administration & dosage
  • Middle Aged
  • Phosphoramide Mustards / administration & dosage
  • Prednisolone / administration & dosage
  • Prednisone / administration & dosage
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Time Factors
  • Treatment Outcome
  • Vincristine / administration & dosage

Substances

  • Phosphoramide Mustards
  • Bleomycin
  • Vincristine
  • Etoposide
  • Lomustine
  • Dexamethasone
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone
  • Cisplatin
  • Melphalan
  • Leucovorin
  • Prednisone
  • Methotrexate

Supplementary concepts

  • CAP protocol 1
  • CAVP protocol
  • CHOP protocol
  • M-BACOD protocol
  • VAP protocol