Abstract
1. The effects of the NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on NK1-agonist evoked contractions were compared in isolated rings of guinea-pig tracheal smooth muscle. 2. (+/-)-CP 96,345 and CP 99,994 were similarly effective in antagonizing responses evoked by septide, whereas CP 99,994 was more effective than (+/-)-CP 96,345 in inhibiting responses evoked by [Sar9Met11(O2)] substance P. 3. These results suggest that responses to septide and [Sar9Met11(O2)] substance P may be operated via different populations of NK1-receptors.
MeSH terms
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Animals
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Biphenyl Compounds / pharmacology*
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Guinea Pigs
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In Vitro Techniques
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Indoles / pharmacology
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Isoindoles
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Neurokinin A / antagonists & inhibitors*
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Neurokinin-1 Receptor Antagonists*
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Peptide Fragments / antagonists & inhibitors
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Peptide Fragments / pharmacology
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Piperidines / pharmacology*
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Pyrrolidonecarboxylic Acid / analogs & derivatives
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Substance P / analogs & derivatives
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Substance P / antagonists & inhibitors
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Substance P / pharmacology
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Trachea / drug effects
Substances
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Biphenyl Compounds
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Indoles
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Isoindoles
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Neurokinin-1 Receptor Antagonists
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Peptide Fragments
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Piperidines
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substance P, Sar(9)-Met(O2)(11)-
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7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one
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3-(2-methoxybenzylamino)-2-phenylpiperidine
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Substance P
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septide
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Neurokinin A
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Pyrrolidonecarboxylic Acid
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CP 96345