Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial

Hum Gene Ther. 1994 Apr;5(4):501-19. doi: 10.1089/hum.1994.5.4-501.
No abstract available

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I

MeSH terms

  • Adenovirus E1 Proteins / genetics*
  • Adenoviruses, Human / genetics*
  • Adult
  • Animals
  • Bronchi / pathology
  • Cell Transplantation
  • Cells, Cultured
  • Chick Embryo
  • Clinical Protocols
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / pathology
  • Cystic Fibrosis / therapy*
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Female
  • Gene Deletion*
  • Genetic Therapy*
  • Genetic Vectors*
  • Guinea Pigs
  • Humans
  • Lung / pathology*
  • Macaca mulatta
  • Male
  • Membrane Proteins / deficiency
  • Membrane Proteins / genetics*
  • Mice
  • Mice, Transgenic
  • Recombinant Fusion Proteins
  • Risk
  • Safety
  • Transplantation, Heterologous

Substances

  • Adenovirus E1 Proteins
  • CFTR protein, human
  • Membrane Proteins
  • Recombinant Fusion Proteins
  • Cystic Fibrosis Transmembrane Conductance Regulator