Abstract
In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia species. Its structure was elucidated by spectroscopic methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (Ki 346 microM) and Moloney murine leukemia virus (Ki 112 microM) reverse transcriptases. In addition, cytotoxic and antifungal activities were observed.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Avian Myeloblastosis Virus / enzymology
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Basidiomycota / growth & development*
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Fermentation
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HIV Reverse Transcriptase
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HIV-1 / enzymology
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Kinetics
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Moloney murine leukemia virus / enzymology
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Mutagenicity Tests
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Reverse Transcriptase Inhibitors*
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Salmonella typhimurium / drug effects
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Yeasts / enzymology
Substances
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Reverse Transcriptase Inhibitors
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Sesquiterpenes
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hyphodontal
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HIV Reverse Transcriptase