Inhibition of endogenous dopamine release in amphibian retina by L-2-amino-4-phosphonobutyric acid (L-AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD)

Brain Res. 1994 Jun 27;649(1-2):339-42. doi: 10.1016/0006-8993(94)91084-7.

Abstract

The metabotropic glutamate receptor agonists 2-amino-4-phosphonobutyric acid (AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD) blocked light-stimulated dopamine release from Xenopus laevis retina. ACPD suppressed release in darkness but AP4 did not. AP4 blocked release stimulated in darkness by picrotoxin, a GABA-A receptor antagonist. The data suggest that regulation of dopamine release in Xenopus retina involves subpopulations of metabotropic glutamate receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aminobutyrates / pharmacology*
  • Animals
  • Cycloleucine / analogs & derivatives*
  • Cycloleucine / pharmacology
  • Dopamine / metabolism*
  • Ion Channels / drug effects
  • Ion Channels / metabolism
  • Light
  • Neurotoxins / pharmacology*
  • Picrotoxin / pharmacology
  • Receptors, Metabotropic Glutamate / agonists*
  • Retina / metabolism*
  • Retinal Cone Photoreceptor Cells / drug effects
  • Retinal Cone Photoreceptor Cells / metabolism
  • Retinal Rod Photoreceptor Cells / drug effects
  • Retinal Rod Photoreceptor Cells / metabolism
  • Stereoisomerism
  • Xenopus laevis

Substances

  • Aminobutyrates
  • Ion Channels
  • Neurotoxins
  • Receptors, Metabotropic Glutamate
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • Picrotoxin
  • 2-amino-4-phosphonobutyric acid
  • Dopamine