Human and mouse T-cell-receptor loci: the importance of comparative large-scale DNA sequence analyses

Cold Spring Harb Symp Quant Biol. 1993:58:339-48. doi: 10.1101/sqb.1993.058.01.040.

Abstract

It is our belief that large-scale DNA sequencing will revolutionize the study of molecular biology, developmental biology, genetics, and evolution for the TCR gene families and, indeed, all multigene families. We also stress the power of comparative analyses for large-scale DNA sequencing efforts.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Biological Evolution
  • Chromosome Mapping
  • Conserved Sequence
  • DNA / genetics*
  • Genes, Regulator
  • Humans
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Pseudogenes
  • RNA / genetics
  • Receptors, Antigen, T-Cell / genetics*
  • Sequence Analysis, DNA*
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic
  • Trypsinogen / genetics

Substances

  • Receptors, Antigen, T-Cell
  • RNA
  • Trypsinogen
  • DNA