Abstract
The records were reviewed of 58 patients receiving transplants in Seattle with unmanipulated marrow from HLA-identical siblings during the accelerated phase (AP) of chronic myeloid leukemia. Variables examined for association with survival and relapse included the interval from diagnosis to transplant, the reasons for categorization as AP, age, regimen, and cytomegalovirus serology. Four patients relapsed. The 4-year probabilities of survival, relapse-free survival, nonrelapse mortality, and relapse were 0.49, 0.43, 0.51, and 0.12, respectively. After completion of the stepwise multivariate analysis, age less than 38 years and categorization as AP solely on the basis of chromosomal abnormalities emerged as being independently significantly associated with improved survival. The 4-year probability of survival for the 16 patients categorized as AP because of chromosomal abnormalities and receiving transplant less than 1 year from diagnosis was 0.74. The low probability of relapse in these patients suggests that more aggressive preparative regimens are not indicated for patients receiving transplants in AP because of the increased risk of transplant-related mortality.
Publication types
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Clinical Trial
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Clinical Trial, Phase I
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Clinical Trial, Phase II
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Comparative Study
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acute Disease
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Adult
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Bone Marrow Transplantation* / mortality
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Busulfan / administration & dosage
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Busulfan / adverse effects
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Busulfan / therapeutic use
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Cause of Death
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Child
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects
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Female
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Graft vs Host Disease / prevention & control
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
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Humans
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Immunologic Factors / therapeutic use
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Infections / etiology
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Infections / mortality
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Interferons / therapeutic use
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
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Leukemia, Myeloid, Accelerated Phase / mortality
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Leukemia, Myeloid, Accelerated Phase / therapy*
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Life Tables
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Male
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Middle Aged
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Multivariate Analysis
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Prognosis
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Recombinant Proteins / therapeutic use
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Retrospective Studies
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Salvage Therapy
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Spleen / pathology
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Splenectomy
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Survival Analysis
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Time Factors
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Treatment Outcome
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Washington / epidemiology
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Whole-Body Irradiation / adverse effects
Substances
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Immunologic Factors
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor
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Cyclophosphamide
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Interferons
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Busulfan