The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815)

H Teshigawara; Y Moriya

doi:10.1016/0306-3623(94)90087-6

The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815)

Gen Pharmacol. 1994 Sep;25(5):857-64. doi: 10.1016/0306-3623(94)90087-6.

Authors

H Teshigawara¹, Y Moriya

Affiliation

¹ Department of Pharmacology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

PMID: 7530673
DOI: 10.1016/0306-3623(94)90087-6

Abstract

1. A biphasic change of compound 48/80-induced histamine release was observed in mastocytoma cell line (P-815). 2. The first and second phase of compound 48/80-induced histamine release were elicited via a different pathway. 3. The second phase of compound 48/80-induced histamine release was provoked with leukotriene (LT) C4. 4. The results suggest that this biphasic release may be one of the important regulatory mechanisms for the production of histamine.

MeSH terms

Animals
Benzoquinones / pharmacology
Dose-Response Relationship, Drug
Histamine Release / drug effects*
Indomethacin / pharmacology
Leukotriene C4 / physiology*
Leukotrienes / pharmacology
Mast-Cell Sarcoma / metabolism*
Mice
Phospholipases A / physiology
Substance P / pharmacology
Tumor Cells, Cultured
p-Methoxy-N-methylphenethylamine / pharmacology

Substances

Benzoquinones
Leukotrienes
Leukotriene C4
Substance P
p-Methoxy-N-methylphenethylamine
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone
Phospholipases A
Indomethacin