This study was conducted to assess the clinical reliability of the prostatic Urolume Wallstent for symptomatic BPH patients. One hundred patients were treated under intravenous sedation or local anesthesia. Pre- and postoperative patient evaluation included scoring of subjective symptoms, physical examination, laboratory analysis, transrectal ultrasonography, uroflowmetry with maximum flow nomograms, intravenous pyelogram and cystourethroscopy. At the long-term follow-up the vast majority of patients showed non-obstructed voiding parameters. The most frequent complications included stent malpositioning and dislocation, and persistent irritative symptomatology. The prostatic UroLume Wallstent is a safe and effective minimally invasive procedure for carefully selected BPH patients.