Abstract
Drugs used to modify the immune response in solid organ transplantation or autoimmune disease may cause dose-related nephrotoxicity. Cyclosporine, FK506, cyclosporine G, and rapamycin have all been studied experimentally and to a more limited extent in patients. This paper summarizes this literature using data from clinically relevant animal models.
MeSH terms
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Acute Kidney Injury / chemically induced*
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Animals
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Cyclosporine / adverse effects
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Humans
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Hypertension, Renal / chemically induced
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Immunosuppressive Agents / adverse effects*
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Kidney Failure, Chronic / chemically induced
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Polyenes / adverse effects
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Sirolimus
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Tacrolimus / adverse effects
Substances
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Immunosuppressive Agents
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Polyenes
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cyclosporin G
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Cyclosporine
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Sirolimus
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Tacrolimus