Abstract
The prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection was investigated in 63 Japanese patients with hepatocellular carcinoma (HCC). HBV infection was confirmed by measuring hepatitis B surface antigen and HBV-DNA in the serum, and HCV infection was confirmed by measuring antibody to HCV using a 2nd generation test and HCV-RNA in serum. Some 54.0% of the patients had HCV infection only, 27.0% had HBV infection only, and 9.5% had both HCV and HBV infection. Only 9.5% of HCC patients had neither HCV nor HBV markers. These results indicate that, in Japan, HCV and HBV infection is an important factor associated with HCC, and that the hepatitis virus may have a role in the carcinogenesis of HCC.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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Biomarkers / blood
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Carcinoma, Hepatocellular / blood
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Carcinoma, Hepatocellular / complications
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Carcinoma, Hepatocellular / diagnosis
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Carcinoma, Hepatocellular / epidemiology*
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Carcinoma, Hepatocellular / virology
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DNA, Viral / analysis
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Female
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Hepacivirus / genetics
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Hepacivirus / isolation & purification
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Hepatitis Antibodies / blood
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Hepatitis B / blood
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Hepatitis B / complications
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Hepatitis B / diagnosis
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Hepatitis B / epidemiology*
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Hepatitis B / virology
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Hepatitis B Surface Antigens / blood
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Hepatitis B virus / genetics
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Hepatitis B virus / isolation & purification
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Hepatitis C / blood
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Hepatitis C / complications
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Hepatitis C / diagnosis
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Hepatitis C / epidemiology*
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Hepatitis C / virology
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Hepatitis C Antibodies
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Humans
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Japan / epidemiology
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Liver Neoplasms / blood
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Liver Neoplasms / complications
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Liver Neoplasms / diagnosis
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Liver Neoplasms / epidemiology*
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Liver Neoplasms / virology
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Male
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Middle Aged
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Molecular Sequence Data
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Polymerase Chain Reaction
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Prevalence
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RNA, Viral / analysis
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Survival Rate
Substances
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Biomarkers
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DNA, Viral
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Hepatitis Antibodies
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Hepatitis B Surface Antigens
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Hepatitis C Antibodies
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RNA, Viral