Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids

J Neural Transm Gen Sect. 1994;96(2):125-33. doi: 10.1007/BF01277934.

Abstract

We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was 0.1 IU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afferent Pathways / physiopathology
  • Animals
  • Calcitonin / administration & dosage
  • Calcitonin / pharmacology*
  • Calcitonin / therapeutic use
  • Dose-Response Relationship, Drug
  • Excitatory Amino Acid Agonists / administration & dosage
  • Excitatory Amino Acid Agonists / toxicity*
  • Injections, Intraventricular
  • Injections, Spinal
  • Kainic Acid / administration & dosage
  • Kainic Acid / antagonists & inhibitors
  • Kainic Acid / toxicity
  • Male
  • Mice
  • N-Methylaspartate / administration & dosage
  • N-Methylaspartate / antagonists & inhibitors
  • N-Methylaspartate / toxicity
  • Pain / chemically induced
  • Pain / physiopathology
  • Pain / prevention & control*
  • Pain Measurement
  • Quisqualic Acid / administration & dosage
  • Quisqualic Acid / antagonists & inhibitors
  • Quisqualic Acid / toxicity
  • Receptors, Glutamate / drug effects*
  • Receptors, Neurokinin-1 / drug effects*
  • Spinal Cord / physiopathology
  • Substance P / administration & dosage
  • Substance P / antagonists & inhibitors
  • Substance P / toxicity*
  • Tail

Substances

  • Excitatory Amino Acid Agonists
  • Receptors, Glutamate
  • Receptors, Neurokinin-1
  • Substance P
  • N-Methylaspartate
  • salmon calcitonin
  • Quisqualic Acid
  • Calcitonin
  • Kainic Acid