Abstract
The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-4, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance.
MeSH terms
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Adenocarcinoma, Follicular / chemistry
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Adenocarcinoma, Follicular / pathology
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Adenocarcinoma, Papillary / chemistry*
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Adenocarcinoma, Papillary / pathology
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Adenoma / chemistry
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Adenoma / pathology
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Antibodies, Monoclonal / analysis
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Antibodies, Monoclonal / immunology
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Cell Adhesion
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Cell Adhesion Molecules / analysis
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Cell Adhesion Molecules / immunology
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E-Selectin
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Epithelium / chemistry
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Epithelium / pathology
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Humans
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Immunohistochemistry
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Intercellular Adhesion Molecule-1 / analysis*
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Intercellular Adhesion Molecule-1 / immunology
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Lymphocyte Function-Associated Antigen-1 / analysis
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Lymphocyte Function-Associated Antigen-1 / immunology
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Receptors, Very Late Antigen / analysis
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Receptors, Very Late Antigen / immunology
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Thyroid Gland / chemistry
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Thyroid Gland / cytology
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Thyroid Gland / pathology
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Thyroid Neoplasms / chemistry*
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Thyroid Neoplasms / pathology
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Vascular Cell Adhesion Molecule-1
Substances
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Antibodies, Monoclonal
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Cell Adhesion Molecules
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E-Selectin
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Lymphocyte Function-Associated Antigen-1
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Receptors, Very Late Antigen
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Vascular Cell Adhesion Molecule-1
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Intercellular Adhesion Molecule-1