Recurrent anaplastic ependymoma with an abnormal karyotype and c-myc proto-oncogene overexpression

M Debiec-Rychter; J Lasota; J Alwasiak; P P Liberski

doi:10.1007/BF00309343

Recurrent anaplastic ependymoma with an abnormal karyotype and c-myc proto-oncogene overexpression

Acta Neuropathol. 1995;89(3):270-4. doi: 10.1007/BF00309343.

Authors

M Debiec-Rychter¹, J Lasota, J Alwasiak, P P Liberski

Affiliation

¹ Department of Oncology, Medical Academy of Lodz, Poland.

PMID: 7538722
DOI: 10.1007/BF00309343

Abstract

Cytogenetic analysis on a supratentorial, recurrent, anaplastic ependymoma from a 29-year-old female disclosed the presence of an abnormal clone with the karyotype 46,XX,der(8)t(8;11)(q24;p11),-11,add(?)t(?;11)(?;q13). By the Northern hybridization assay and immunohistochemical staining, tumor cells revealed overexpression of c-myc proto-oncogene, although no evidence of amplification or structural rearrangement of this gene was found.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blotting, Northern
Brain Neoplasms / genetics*
Brain Neoplasms / metabolism*
Brain Neoplasms / pathology
Ependymoma / genetics*
Ependymoma / metabolism*
Ependymoma / pathology
Female
Humans
Immunohistochemistry / methods
Karyotyping*
Microscopy, Electron
Neoplasm Recurrence, Local
Proto-Oncogene Mas
Proto-Oncogene Proteins c-myc / metabolism*
Staining and Labeling

Substances

MAS1 protein, human
Proto-Oncogene Mas
Proto-Oncogene Proteins c-myc