Abstract
Heparan sulphate binding to Helicobacter pylori at pH 4 to 5 was inhibited with various sulphated polysaccharides (heparin and chondroitin sulphates, fucoidan, carrageenans and some others), but not by carboxylated or nonsulphated compounds. Heparin binding proteins are exposed on the cell surface.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Adhesion / drug effects*
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Bacterial Outer Membrane Proteins / chemistry
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Binding, Competitive
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Carrageenan / pharmacology
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Cattle
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Chondroitin Sulfates / pharmacology
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Dextran Sulfate / pharmacology
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Dose-Response Relationship, Drug
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Helicobacter pylori / physiology*
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Heparin / pharmacology
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Heparitin Sulfate / metabolism*
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Pentosan Sulfuric Polyester / pharmacology
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Polysaccharides / pharmacology*
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Sulfuric Acid Esters / pharmacology*
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Xylans / pharmacology
Substances
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Bacterial Outer Membrane Proteins
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Polysaccharides
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Sulfuric Acid Esters
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Xylans
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Pentosan Sulfuric Polyester
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Carrageenan
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Heparin
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Chondroitin Sulfates
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Dextran Sulfate
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Heparitin Sulfate
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fucoidan