Regulation of development, survival and neoplastic growth of mast cells through the c-kit receptor

Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):54-6. doi: 10.1159/000236929.

Abstract

Signaling through the c-kit receptor tyrosine kinase (Kit) is essential for development and survival of mast cells but not of basophils. Moreover, we recently found an activation mutation of Kit in several tumor mast cell lines.

Publication types

  • Review

MeSH terms

  • Animals
  • Basophils / cytology
  • Cell Differentiation
  • Cell Survival
  • Cell Transformation, Neoplastic / pathology*
  • Leukemia, Mast-Cell / pathology
  • Mast Cells / cytology*
  • Mast Cells / pathology
  • Mast-Cell Sarcoma / pathology
  • Mice
  • Mice, Transgenic
  • Nippostrongylus
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Proto-Oncogene Proteins / deficiency
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-kit
  • Rats
  • Rats, Mutant Strains
  • Rats, Nude
  • Receptor Protein-Tyrosine Kinases / deficiency
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / physiology*
  • Receptors, Colony-Stimulating Factor / deficiency
  • Receptors, Colony-Stimulating Factor / genetics
  • Receptors, Colony-Stimulating Factor / physiology*
  • Signal Transduction
  • Strongylida Infections / immunology
  • Strongylida Infections / pathology
  • Tumor Cells, Cultured

Substances

  • Proto-Oncogene Proteins
  • Receptors, Colony-Stimulating Factor
  • Proto-Oncogene Proteins c-kit
  • Receptor Protein-Tyrosine Kinases