Abstract
Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7"-di-O-methylamentoflavone, isocryptomerin and 7"-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2",3"-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / toxicity
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Cell Line
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Flavonoids / isolation & purification*
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Flavonoids / toxicity*
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Humans
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Lung Neoplasms
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Optical Rotation
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Plant Leaves
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Plants, Medicinal*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Flavonoids