Abstract
Acute psychosis was observed in two patients with AIDS who were treated with clarithromycin for disseminated Mycobacterium avium complex infection. The psychosis resolved when treatment with clarithromycin was discontinued and recurred when it was resumed. An adverse response to clarithromycin therapy is a rare but curable cause of acute psychosis in patients with AIDS.
MeSH terms
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AIDS-Related Opportunistic Infections / drug therapy*
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Adult
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Bipolar Disorder / chemically induced*
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Bipolar Disorder / complications
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Clarithromycin / adverse effects*
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Clarithromycin / therapeutic use
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Humans
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Male
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Mycobacterium avium Complex / isolation & purification
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Mycobacterium avium-intracellulare Infection / complications
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Mycobacterium avium-intracellulare Infection / drug therapy*