Abstract
Serum tryptase (Tryp) and eosinophil cationic protein (ECP) and urine N-methylhistamine (N-MH) were quantitated in a group of 13 subjects who had experienced immediate allergic reactions to different drugs. Results indicated that both Tryp and N-MH were involved and the levels were related to the severity of the reaction. Results of serum ECP levels failed to provide relevant information concerning the participation of eosinophils in immediate reactions to drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Biomarkers / blood
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Biomarkers / urine
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Blood Proteins / metabolism*
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Blood Proteins / urine
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Chymases
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Drug Hypersensitivity / blood
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Drug Hypersensitivity / metabolism*
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Drug Hypersensitivity / urine
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Eosinophil Granule Proteins
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Female
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Humans
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Inflammation Mediators / metabolism*
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Inflammation Mediators / urine
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Male
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Methylhistamines / metabolism*
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Methylhistamines / urine
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Middle Aged
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Ribonucleases*
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Sensitivity and Specificity
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Serine Endopeptidases / blood
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Serine Endopeptidases / metabolism*
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Time Factors
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Tryptases
Substances
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Biomarkers
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Blood Proteins
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Eosinophil Granule Proteins
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Inflammation Mediators
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Methylhistamines
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Ribonucleases
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Serine Endopeptidases
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chymase 2
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Chymases
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Tryptases
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N-methylhistamine