Response to interferon therapy in children with chronic hepatitis C

T Fujisawa; A Inui; T Ohkawa; H Komatsu; Y Miyakawa; M Onoue

doi:10.1016/s0022-3476(95)70135-4

Response to interferon therapy in children with chronic hepatitis C

J Pediatr. 1995 Oct;127(4):660-2. doi: 10.1016/s0022-3476(95)70135-4.

Authors

T Fujisawa¹, A Inui, T Ohkawa, H Komatsu, Y Miyakawa, M Onoue

Affiliation

¹ Department of Pediatrics, National Defense Medical College, Saitama, Japan.

PMID: 7562297
DOI: 10.1016/s0022-3476(95)70135-4

Abstract

We evaluated the effect of interferon therapy and investigated factors that may influence the outcome in 18 children with chronic hepatitis C. A complete response was obtained in 10 children (56%). The titer for pretreatment serum virus ribonucleic acid (< or = 10(7) copies/ml) was correlated significantly with a complete response to therapy.

MeSH terms

Alanine Transaminase / blood
Alanine Transaminase / metabolism
Child
Child, Preschool
Chronic Disease
Female
Genotype
Hepatitis C / blood
Hepatitis C / drug therapy*
Hepatitis C / physiopathology
Humans
Immunoglobulin M
Interferons / therapeutic use*
Liver / enzymology
Liver / physiopathology
Liver Function Tests
Male
Polymerase Chain Reaction
RNA, Viral
Treatment Outcome

Substances

Immunoglobulin M
RNA, Viral
Interferons
Alanine Transaminase