Abstract
Administration of human gonadotropins such as hFSH, hLH, and hCG to rhesus macaques can result in formation of anti-human gonadotropin antibodies. To determine whether the presence of these antibodies interferes with subsequent fertility, sixteen female rhesus macaques (Macaca mulatta) with known antibody levels were bred with male rhesus macaques. The presence of antibodies did not interfere with conception or maintenance of pregnancy. Furthermore, antibody titers did not increase during gestation or following the resolution of pregnancy.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibody Formation*
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Chorionic Gonadotropin / immunology*
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Chorionic Gonadotropin / pharmacology
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Female
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Fertility / immunology*
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Fertility Agents, Female / immunology*
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Fertility Agents, Female / pharmacology
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Fertilization in Vitro / veterinary*
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Follicle Stimulating Hormone / immunology*
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Follicle Stimulating Hormone / pharmacology
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Humans
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Luteinizing Hormone / immunology*
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Luteinizing Hormone / pharmacology
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Macaca mulatta
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Male
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Ovarian Follicle / drug effects
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Ovarian Follicle / physiology
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Pregnancy
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Pregnancy, Animal / immunology*
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Reference Values
Substances
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Chorionic Gonadotropin
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Fertility Agents, Female
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Luteinizing Hormone
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Follicle Stimulating Hormone