Abstract
Insulin release from pancreatic islet cells of neonatal rats could be markedly inhibited by a previous incubation of cells with interleukin-1 beta (5-20 U/ml) for 20 h even under high glucose (20 mmol/L) stimulation. This inhibitory effect of IL-1 beta on insulin release could be reversed by testosterone (10(-10) mol/L), which was accompanied by an increase of the insulin content in islet cells.
MeSH terms
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Animals
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Animals, Newborn
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Cells, Cultured
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Insulin / metabolism*
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Insulin Secretion
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Interleukin-1 / pharmacology*
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Interleukin-1beta
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Islets of Langerhans / cytology
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Islets of Langerhans / metabolism*
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Peptide Fragments / pharmacology*
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Rats
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Rats, Wistar
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Testosterone / pharmacology*
Substances
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Insulin
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Interleukin-1
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Interleukin-1beta
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Peptide Fragments
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interleukin-1beta (163-171)
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Testosterone