Abstract
Immunoglobulin allotype frequencies were determined in well characterised groups of responders (n = 160) and non-responders (n = 32) to Rh(D) antigen immunisation. Allotype frequencies in these groups were compared with frequencies in a normal control population (n = 500). No significant differences in allotype frequencies were observed between the responder and non-responder groups, or when these two groups where compared with a normal control population. These results suggest that the immunoglobulin heavy-chain genes do not influence the anti-Rh(D) immune response.
MeSH terms
-
Female
-
Haplotypes / immunology
-
Humans
-
Immunoglobulin Allotypes / biosynthesis*
-
Immunoglobulin Allotypes / genetics
-
Immunoglobulin G / biosynthesis
-
Immunoglobulin G / genetics
-
Immunoglobulin Gm Allotypes / biosynthesis
-
Immunoglobulin Gm Allotypes / genetics
-
Isoantibodies / biosynthesis*
-
Isoantibodies / genetics*
-
Male
-
Rh-Hr Blood-Group System / genetics
-
Rh-Hr Blood-Group System / immunology*
-
Rho(D) Immune Globulin
Substances
-
Immunoglobulin Allotypes
-
Immunoglobulin G
-
Immunoglobulin Gm Allotypes
-
Isoantibodies
-
RHO(D) antibody
-
Rh-Hr Blood-Group System
-
Rho(D) Immune Globulin
-
Rho(D) antigen