Conservative and curative management of rectal adenocarcinomas by local radiotherapy alone

Eur J Cancer. 1995 Jul-Aug;31A(7-8):1340-2. doi: 10.1016/0959-8049(95)00253-f.

Abstract

Two hundred patients with well-differentiated adenocarcinomas of the rectum stages T1, T2 (113 T1, 87 T2) were accrued in two French institutions (Lyon-Sud and Dijon). Treatment consisted of intracavitary 50 kV X-rays (90-120 Gy in 3-4 fractions and 4-6 weeks). A 20-30 Gy interstitial brachytherapy boost was given after 2-3 fractions when a limited infiltration of the rectal wall was present. Local failure occurred in 4.4% of T1, 19.5% of T2; nodal failure in 0.9% of T1, 9.2% of T2. Ultimate local control after salvage of failures is 94.5%. A functional sphincter was preserved in 95% of patients with local control.

Publication types

  • Multicenter Study

MeSH terms

  • Adenocarcinoma / pathology
  • Adenocarcinoma / radiotherapy*
  • Anal Canal / physiopathology
  • Brachytherapy / methods*
  • Humans
  • Lymphatic Metastasis
  • Neoplasm Recurrence, Local
  • Rectal Neoplasms / pathology
  • Rectal Neoplasms / radiotherapy*