Abstract
The past year has seen advances in delineating the clinical features, natural history and imaging characteristics of multiple system atrophy. The initiating pathogenetic mechanisms remain unknown. However, any aetiological or pathophysiological hypothesis must consider not only neuronal loss and gliosis but also the recently described characteristic oligodendrolial cytoplasmic inclusions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Brain / pathology
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Brain / physiopathology
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Corpus Striatum / pathology
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Corpus Striatum / physiopathology*
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Diagnosis, Differential
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Diagnostic Imaging
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Humans
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Inclusion Bodies / pathology
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Nerve Degeneration / physiology*
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Neurologic Examination
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Oligodendroglia / pathology
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Olivopontocerebellar Atrophies / diagnosis*
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Olivopontocerebellar Atrophies / pathology
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Olivopontocerebellar Atrophies / physiopathology
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Shy-Drager Syndrome / diagnosis*
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Shy-Drager Syndrome / pathology
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Shy-Drager Syndrome / physiopathology
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Substantia Nigra / pathology
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Substantia Nigra / physiopathology*