Abstract
We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED50 approximately 0.7 microgram kg-1) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692.
MeSH terms
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Administration, Oral
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Animals
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Defecation / drug effects*
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Diet
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Dose-Response Relationship, Drug
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Feces / chemistry
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Food Deprivation
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Gastric Emptying / drug effects*
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Indoles / administration & dosage
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Indoles / pharmacology
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Injections, Subcutaneous
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Male
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Pyrazoles / administration & dosage
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Pyrazoles / pharmacology*
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Quinolines / administration & dosage
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Quinolines / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Receptors, Neurotensin / antagonists & inhibitors*
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Serotonin Antagonists / administration & dosage
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Serotonin Antagonists / pharmacology
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Tropisetron
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Water / metabolism
Substances
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Indoles
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Pyrazoles
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Quinolines
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Receptors, Neurotensin
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Serotonin Antagonists
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Water
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SR 48692
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Tropisetron